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Abhigyan Som
Post-Doctoral Researcher

Degree Information: Ph.D., Organic Chemistry, University of Geneva, Switzerland, 2004 M.S., Chemistry, Indian Institute of Technology, Kanpur, India, 1999 B.S., Chemistry, Presidency College, Kolkata, India, 1997 Mailing Address: Department of Polymer Science and Engineering Room A622, Conte Research Center University of Massachusetts Amherst 120 Governors Drive Amherst, MA 01003 Phone: 413-577-1633 Email: som_at_polysci.umass.edu Fax: 413-545-0082

Click here for my C.V.

Honors and Awards:

• Cover picture: Biopolymers (Peptide Science) 2008, 90 (2).
• Cover picture:  Advanced. Functional Materials 2006, 16 (2).
• Cover picture:  Tetrahedron 2004, 60 (31).
• Most cited paper 2003-2006 award:  Tetrahedron 2004, 60, 6405-6435.
• Best poster award:  Swiss Chemical Society October 17, 2002, Basel, Switzerland.
• Qualified GATE 1999 in Chemistry with 99.28 percentile (All India rank 12th).

Publications:

• Calcium Triggered Membrane Activity in Cardiolipin Vesicles by Antimicrobial Oligomers and Antimicrobial Peptides.  Som, A.; Tew, G. N.  in preparation.
• Synthetic Mimics of Antimicrobial Peptides.  Som, A; Vemparala, S.; Ivanov, I.: Tew, G. N. Biopolymers (Pept. Sci.) 2008, 90, 83-93. (cover picture).
• Influence of Lipid Composition on Membrane Activity of Antimicrobial Phenylene Ethynylene Oligomers.  Som, A.; Tew, G. N.  submitted to J. Phys. Chem. B.
• Synthesis of Quaternary Pyridinium Polymers Based on Norbornene Derivatives.  Eren, T.; Som, A.; Rennie, J.; Urgina, Y.; Tew, G. N.; Coughlin, B. E.  submitted to Macromol. Chem. Phys.
• Synthetic Antimicrobial Oligomers Induce Composition Dependent Topological Transition in Membranes.  Yang, L.; Gordon, V. D.; Mishra, A.; Som, A.; Purdy, K.; Davis, M. A.; Tew, G. N.; Wong, G. C. L.  J. Am. Chem. Soc. 2007, 129, 12141-12147.
• Infectious Disease: Connecting Innate Immunity to Biocidal Polymers.  Gabriel, G.; Som, A.; Madkour, A.; Eren, T.; Tew, G. N.  Mater. Sci. Eng. R. 2007, 57, 28-64.
• Molecular Recognition by Synthetic Multifunctional Pores in Practice:  Are Structural Studies Really Helpful?  Baudry, Y.; Bollot, G.; Gorteau, V.; Litvinchuk, S.; Mareda, J.; Nishihara, M.; Pasini, D.; Perret, F.; Ronan, D.; Shah, R. M.; Sakai, N.; Som, A.; Sordé, N.; Talukdar, P.; Tran, D. H.; Matile, S.  Adv. Funct. Mater. 2006, 16, 169-179.  (cover picture)
• Contribution of Lipid Bilayer Hosts to Structure and Activity of Multifunctional Supramolecular Guests.  Som, A.; Matile, S. Chem. Biodiv. 2005, 2, 717-729.
• On Thermodynamic and Kinetic Stability of Synthetic Multifunctional Rigid Rod b-Barrel Pores: Evidence for Supramolecular Catalysis.  Litvinchuk, S.; Bollot, G.; Mareda, J.; Som, A.; Ronan, D.; Shah, R. M.; Perrottet, P.; Sakai, N.; Matile, S. J. Am. Chem. Soc. 2004, 126, 10067-10075.
• Recent Synthetic Ion Channels and Pores.  Matile, S.; Som, A.; Sordé, N. Tetrahedron 2004, 60, 6405-6435.  (cover picture) recipient of the most cited paper 2003-2006 award.
• Catalytic Rigid-Rod b-Barrels with Hydrazide Cofactors to Convert Poor Substrates as Hydrazone Conjugates.  Som, A.; Talukdar, P.; Baumeister, B.; Matile, S. Chimia 2003, 57, 208-209.
• Complementary Characteristics of Homologous p-Octiphenyl b-Barrels with Ion Channel and Esterase Activity.  Som, A.; Sakai, N.; Matile, S. Bioorg. Med. Chem. 2003, 11, 1363-1369.
• Rigid-Rod b-Barrel Ion Channels with Internal “Cascade Blue” Cofactors – Catalysis of Amide, Carbonate, and Ester Hydrolysis.  Som, A.; Matile, S. Eur. J. Org. Chem. 2002, 3874-3883.
• On the Importance of Intermediate Internal Charge Repulsion for the Synthesis of Multifunctional Pores.  Baumeister, B.; Som, A.; Das, G.; Vilbois, F.; Gerard, D.; Shahi, S. P.; Matile, S. Helv. Chim. Acta 2002, 85, 2740-2753.
• Bioorganic Chemistry of Rigid-Rod Molecules: Adventures with p-Oligophenyls.  Baudry, Y.; Baumeister, B.; Das, G.; Gerard, D.; Matile, S.; Sakai, N.; Som, A.; Sordé, N.; Talukdar, P.  Chimia 2002, 56, 667-671.
• Functionalization of a Heteroditopic Cryptand: Exocyclic Coordination with Iron(III).  Tripathi, P.; Som, A.; Bharadwaj, P. K.  Proc. Indian Acad. Sci. (Chem. Sci.) 2000, 112, 385.

 Posters and Presentations:

• Influence of Lipid composition on Membrane Activity of Synthetic Antimicrobial Oligomers.  American Chemical Society 234th National Meeting August 19-23, 2007, Boston, USA.
• Interactions of Antimicrobial Oligomers with Liposomal Membranes.  PSE Annual Poster Symposium October 3-5, 2006, University of Massachusetts, Amherst, USA.
• Interactions of Homologous Amphiphilic Antibiotics with Liposomal Membranes.  PSE Annual Poster Symposium October 11-13, 2005, University of Massachusetts, Amherst, USA.
• Synthetic Multifunctional Pores as Hosts, as Sensors and as Catalysts.  National Research Program “Supramolecualr Functional Materials” July 4, 2003, Bern, Switzerland.
• Rigid-Rod b-Barrel Ion Channels with Internal “Cascade Blue” Cofactors to Catalyze Ester, Amide, and Carbonate Hydrolysis.  Swiss Chemical Society October 17, 2002, Basel, Switzerland. (recipient of the best poster award)
• Rigid-Rod b-Barrel Ion Channels with Internal “Cascade Blue” Cofactors to Catalyze Ester, Amide, and Carbonate Hydrolysis.  "Lipids and Biomembranes:  New Technologies" October 2-5, 2002, Davos, Switzerland.
• Internal Cofactors for p-Oligophenyl b-Barrels with Ion Channel and Esterase Activity.  Oppolzer Lectures October 5, 2001, Geneva, Switzerland.